Available PhD projects

Post-doc and PhD student enquiries will always be considered. Please attach your CV and email Kevin Hardwick.

» PhD studentship
The spindle checkpoint - co-ordination of chromosome segregation with mitotic progression

Cells employ a number of surveillance systems to monitor the fidelity of intracellular processes. The most important of these for chromosome segregation is known as the spindle checkpoint. Yeast genetics identified the Mad and Bub proteins as components of this cell cycle control. These proteins are highly conserved from yeast to human. They are essential for vertebrate development, and when mutated or perturbed can lead to growth defects, aneuploidy, and cancer. We will employ yeast genetics, biochemistry and microscopy to describe the mode of action of the Mad and Bub proteins and thereby understand the molecular mechanism of the spindle checkpoint.


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